mysterious p53 Protein

the most frequently genetic lesions seen in cancers involves the so-called p53 protein which seems to play the major role in cell cyle. The knock out mice with truncated p53, made by homologous recombination , showed relatively high rate of malignant tumor development . The latter results support the hypothesis that this gene is the main factor predisposing the individuals to cancer development . I 'll try to write more about the connection of this gene which is dispensable for development , with the SIR silencing genes which in abberant form accelarate the progeria . its one of Lenny Guarente preassumptions . whatsmore , the p53 might affect the immune system . I have not found any recent review though .